Key Benefits Legend, because of its unique purity, can be given intra-articularly or intravenously. I.V. administration provides the following advantages: Safety No need to invade the joint with a needle, risking bacterial entrance, physical trauma to joint tissues or intra-articular injection reactions. Safety in breeding animals has not been determined. Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use only in horses. Do not use in horses intended for human consumption. Convenience No shaving or surgical preparation of the joint. IV administration to treat multiple joints. Available in a larger, 20mL Multi Dose vial for Intravenous use only. Efficacy Proven to decrease inflammation and destructive enzymes associated with inflammation.1 Rapid onset of action. I.V. administration helps ensure a quick onset of action resulting in a rapid decrease in inflammation. Applications Legend 2mL, For Intravenous and Intra-Articular use Legend 4mL, For Intravenous use only Legend Multi 20mL, For Intravenous use onlyThe intra-articular safety of Legend Multi dose with benzyl alcohol has not been determined.How Supplied: Legend Injectable Solution is supplied in 2 mL 20 mg and 4 mL 40 mg vials. Each mL contains 10 mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. Legend Multi Dose Injectable Solution is supplied in 20 mL vials. Each mL contains 10mg hyaluronate sodium, 8.5 mg sodium chloride, 0.223 mg sodium phosphate dibasic, 0.04 mg sodium phosphate monobasic and 15.63 mg benzyl alcohol as a preservative. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. DOSAGE AND ADMINISTRATION: Legend Multi Dose 20 mL and Legend 4 mL 40mg injected intravenously only. Legend 2 mL 20 mg injected intravenously or intra-articularly in the carpus or fetlock. Treatment may be repeated at weekly intervals for a total of three treatments. Legend Injectable Solution 2 mL: Strict aseptic technique should be observed when administering by intra-articular injection. As with any intra-articular procedure, proper injection site disinfection and animal restraint are important. Excess joint fluid should be aseptically removed prior to injection. Care should be taken to avoid scratching the cartilage surface with the tip of the injection needle. Diffuse swelling lasting 24 to 48 hours may result from movement of the needle while in the joint space. For intravenous administration, use aseptic technique and inject slowly into the jugular vein. Horses should be given stall rest after treatment before gradually resuming normal activity. Legend Injectable Solution 2 mL and 4 mL only: Discard any unused portion of the drug and the empty vial after opening. CONTRAINDICATIONS: There are no known contraindications for the use of Legend® hyaluronate sodium Solution and Legend® Multi Dose hyaluronate sodium Injectable Solution in horses. RESIDUE WARNING: Do not use in horses intended for human consumption. HUMAN WARNINGS: Not for use in humans. Keep this and all other drugs out of reach of children. ANIMAL SAFETY WARNING: For 4 mL only – Not for Intra-articular use. Multi Dose not for Intra-articular use. The Intra-articular safety of hyaluronate sodium with benzyl alcohol has not been evaluated. Legend Injectable 10 mg/ml, 2 ml vial=20mg. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.