Instructions for Use:Sentinel Spectrum should be given once a month, every month of the year. Preferably, Sentinel Spectrum should be given on the same date each month. To ensure complete absorption, always give Sentinel Spectrum chewables to dogs either with or immediately after a normal meal. Food is essential for proper absorption of the product into the bloodstream. Most dogs like the taste of the Sentinel Spectrum chewable and will accept the chewable readily as a treat. The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow the medication without chewing.The chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Dosage:Dogs/puppies: 6 weeks of age or older 2-8 lbs Give 1 chewable every month Orange Box 8.1-25 lbs Give 1 chewable every month Green Box 25.1-50 lbs Give 1 chewable every month Yellow Box 50.1-100 lbs Give 1 chewable every month Blue Box Dogs over 100 lbs Give the appropriate combination of chewables Cautions: Mild, transient hypersensitivity reactions, such as labored breathing, vomiting, hypersalivation, and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating offspring microfilariae. These reactions are presumably caused by release of protein from dead or dying offspring. Do not use in puppies less than six weeks of age. Do not use in dogs or puppies less than two pounds of body weight. The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females. Special Precautions: Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Sentinel Spectrum, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Sentinel Spectrum is not effective against adult D. immitis. Do not use in puppies less than six weeks of age. Do not use in dogs or puppies less than two pounds of body weight. The safety of Sentinel Spectrum has not been evaluated in dogs used for breeding or in lactating females. Possible Drug Interactions: Sentinel is safe to use in dogs at risk for MDRI-allele mutation Australian Shepherds, Collies, Shelties,etc., unless tested normal, caution is advised if the pet is also being given amiodarone Cordarone, azole antifungals such as ketoconazole, carvedilol Coreg, cyclosporine Atopica, diltiazem Cardizem, erthromycin Ery-Tabs or clarithromycin Biaxin, quinidine, spironolactone Adlactone, tamoxifen, and verapamil Calan. Do not give Sentinel Spectrum to your pet if already giving an alternate heartworm medication. Sentinel Spectrum Chewable Blue – 50.1-100 lbs – 6 Doses. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.