What is Cushing's Syndrome?:Hyperadrenocorticism, or Cushing's syndrome, is one of the most commonly diagnosed canine endocrine disorders. Cushing's Syndrome is usually in older dogs and can be either spontaneous or iatrogenic. The signs of Cushing's Syndrome in dogs arise due to an excess of circulating gucocorticoids, particularly cortisol. Cortisol is a hormone produced in the cortex of the adrenal glands. The normal function of cortisol is to help the body respond to stess and change, and also to prepare the body for the flight or fight response. Cortisol movilizes nutrients, modifies the body's response to inflammation, stimulates the liver to raise the blood sugar, and helps control the amount of water in the body.Signs of Cushing's Syndrome:Excess levels of glucocorticoids in the body cause a range of clinical signs that include: polydipsia=increased thirst polyuria=is a condition usually defined as excessive or abnormally large production and/or passage] of urine hypertension pot belly thinning of the skin hair loss recurrent skin diseases lethargy excessive pantingBenefits of Vetoryl: Promising treatment for Cushing's Disease in dogs Treats both pituitary-dependent and adrenal-dependent cases Fewer & less severe side-effects reported than Mitotane Controls excess production of cortisolHow does it work:VETORYL Capsules are available in 3 sizes 10, 30 and 60 mg for oral administration based on body weight. Trilostane 4a, 5a-epoxy-17ß-hydroxy-3-oxoandrostane-2a-carbonitrile is an orally active synthetic steroid analogue that selectively inhibits 3 ß-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent, mineralocorticoids and sex hormones while steroid precursor levels increase. DOSAGE AND ADMINISTRATION: Alwayscompletely read the Client Information Sheet with prescription.The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb 2.2-6.7 mg/kg once a day based on body weight and capsule size. Follow your Veterinarians prescription dosage thatwill be dependent on the weight of your pet.VETORYL Capsules should be administered with food. Individual dose adjustments and close monitoring are essential. Your Veterinarian will Re-examine and conduct an ACTH stimulation test 10-14 days after every dose alteration. Care must be taken during dose increases to monitor the dog's clinical signs and serum electrolyte concentrations. Once daily administration is recommended. However, if clinical signs are not controlled for the full day, twice daily dosing may be needed. To switch from once daily to twice daily dosing, increase the total daily dose by 1/3 to 1/2 and divide the total amount into two doses given 12 hours apart. Long-Term Monitoring Once an optimum dose of VETORYL Capsules has been reached, re-examine the dog at 30 days, 90 days and every 3 months thereafter. At a minimum, this monitoring should include a thorough history and physical examination, ACTH stimulation test conducted 4-6 hours after VETORYL Capsule administration, and serum biochemical tests with particular attention to electrolytes, renal and hepatic function.Good control is indicated by favorable clinical signs as well as post-ACTH serum cortisol of 1.45-9.1 &mug/dL 40-250 nmol/L. CONTRAINDICATIONS: The use of VETORYL Capsules is contraindicated in dogs that have demonstrated hypersensitivity to trilostane. Do not use VETORYL Capsules in animals with primary hepatic disease or renal insufficiency. Do not use in pregnant dogs. Studies conducted with trilostane in laboratory animals have shown teratogenic effects and early pregnancy loss. WARNINGS: mineralocorticoids and intravenous fluids may be required. Angiotensin-converting enzyme ACE inhibitors should be used with caution with VETORYL Capsules, as both drugs have aldosterone-lowering effects which may be additive, impairing the patient's ability to maintain normal electrolytes, blood volume and renal perfusion. Potassium sparing diuretics e.g. spironolactone should not be used with VETORYL Capsules, as both drugs have the potential to inhibit aldosterone, increasing the likelihood of hyperkalemia. HUMAN WARNINGS:Keep out of reach of children. Not for human use. Wash hands after use. Do not empty capsule contents and do not attempt to divide the capsules. Do not handle the capsules if pregnant or if trying to conceive. Trilostane is associated with teratogenic effects and early pregnancy loss in laboratory animals. In the event of accidental ingestion/overdose, seek medical advice immediately and take the labeled container with you. Vetoryl -120 mg 30 count . I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.