Benefits: No pre-cleaning required Only needs to be administered once a day Zymox is antibiotic FREE Broad spectrum antibacterial and antifungal properties Made in USA. Possible Side Effects: There are no reported side effects with Zymox Otic-HC Cautions: Do not clean your pets ears before or during use. Doing so will disrupt the enzyme system.;Do not use this product in conjunction with other topical ear medications or cleaners. Storage: Store in a cool dry place. Zymox Plus Otic Enzymatic Solution with Hydrocortisone -1.25 oz. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.