Key Benefits: 100 percent effective at preventing heartworm disease caused by Dirofilaria immitis, as shown in clinical trials. Up to 100 percent effective treatment and control of hookworm infections caused by Ancylostoma tubaeforme adults, immature adults, and fourth stage larvae and roundworm infections caused by Toxocara cati adults and fourth stage larvae. Proven effective up to 99.5 percent treatment and control of ear mite Otodectes cynotis infestations. Safe and effective, when used topically as directed, for cats and kittens that are at least nine weeks of age and that weigh at least two pounds. Onceamonth, readytouse topical solution packaged in six, singledose applicator tubes for cats weighing 5.1 to nine pounds and 9.1 to 18 lbs. Three, singledose applicator tubes are available for cats/kittens weighing two to five pounds. Important Safety Information: Like all topical animal health treatments, Advantage Multi for Cats, is not to be given to pets orally, is not for human use, and should be kept out of the reach of children. Oral ingestion by cats may result in hypersalivation, tremors, vomiting, and decreased appetite. Children should not come in contact with the application site for 30 minutes after application. Ask your veterinarian if this product is right for your cat.How it works:Advantage Multi® imidacloprid + moxidectin Topical Solution is to be administered monthly, and when applied directly to your pet's skin, prevents heartworm disease, kills adult fleas and controls flea infestations, and treats and controls intestinal worms. The two active ingredients in Advantage Multi are imidacloprid and moxidectin. Imidacloprid has a high affinity for the nicotinic acetylcholine receptors in the postsynaptic region of the nervous system of fleas. The ensuing inhibition of cholinergic transmission in insects i.e., fleas results in paralysis and death. Moxidectin interacts with gabaamniobutyric acid GABA and glutamategated chloride channels. This leads to opening of the chloride channels on the postsynaptic junction, the inflow of chloride ions and induction of an irreversible resting state. The result is flaccid paralysis of susceptible parasites, followed by their death and/or expulsion.How to apply to your Cat:Your veterinarian will determine the correct dosage for your cat by his/her weight. Once a month, the premeasured dose is applied to the surface of the cat's skin. Applying Advantage Multi for Cats is available in three convenient package sizes which offer flexibility in dosing: Kittens/Cats 25 pounds Cats between 5.1 and 9 pounds Cats between 9.1 and 18 pounds * Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes. Once you have the correct premeasured dose from your veterinarian, follow the instructions below. Dosage and Administration:The recommended minimum dose is 4.5 mg/lb 10.0 mg/kg imidacloprid and 0.45mg/lb 1.0mg/kg moxidectin, once a month by topical administration. Do not apply to irritated skin.1.Remove one dose applicator tube from package. Administer the entire contents of the tube that correctly corresponds to the body weight of the cat.2.While holding the tube in an upright position, remove the cap from the tube. 3.Turn the cap over and push the other end of cap onto the tip of the tube. 4.Twist the cap to break the seal and then remove the cap from the tube. 5.Part the hair on the back of the cat's neck at the base of the head until the skin visible.6.Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin.7.Lift the tube away from skin before releasing pressure on tube. Advantage Multi Cat 5-9 lbs – 6 Doses. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.