As with other heartworm preventatives, pets must be tested for heartworms prior to usingAdvantage Multi for DogsKey Benefits: 100 percent effective at preventing heartworm disease caused by Dirofilaria immitis, as shown in clinical trials. 100 percent effective treatment and control of hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala adults, immature adults and fourth stage larvae. Up to 98.2 percent effective treatment and control of roundworm infections caused by Toxocara canis adults and fourth stage larvae. Up to 100 percent effective for the treatment and control roundworm infection caused by Toxascaris leonina adults. Up to 98.6 percent effective treatment and control of whipworm infections caused by Trichuris vulpis adults. Safe and effective, when used topically as directed, for dogs and puppies that are at least seven weeks of age and that weigh at least three pounds. How it works: Advantage Multi® imidacloprid + moxidectin Topical Solution is to be administered monthly, and when applied directly to your pet's skin, prevents heartworm disease, kills adult fleas and controls flea infestations, and treats and controls intestinal worms. The two active ingredients in Advantage Multi are imidacloprid and moxidectin. Imidacloprid has a high affinity for the nicotinic acetylcholine receptors in the postsynaptic region of the nervous system of fleas. The ensuing inhibition of cholinergic transmission in insects i.e., fleas results in paralysis and death. Moxidectin interacts with gabaamniobutyric acid GABA and glutamategated chloride channels. This leads to opening of the chloride channels on the postsynaptic junction, the inflow of chloride ions and induction of an irreversible resting state. The result is flaccid paralysis of susceptible parasites, followed by their death and/or expulsion How to administer to your Dog: Pets and their owners alike will be excited by the convenience of Advantage Multi® for Dogs imidacloprid + moxidectin Topical Solution. Your Veterinarian will determine the correct dosage for your dog by his/her weight. Once a month, the premeasured dose is applied to the surface of the dog's skin. Advantage Multi for Dogs is available in the four different sizes: · Puppies/Dogs 3 9 lbs. GREEN BOX · Puppies/Dogs 9.1 20 lbs. TEAL BOX · Puppies/Dogs 20.1 55 lbs. RED BOX · Dogs over 55.1 lbs. >BLUE BOX Dosage and Administration: The recommended minimum dose is 4.5mg/lb 10.0 mg/kg imidacloprid and 1.1 mg/lb 2.5 mg/kg moxidectin, once a month by topical administration. Do not apply to irritated skinFor dogs less than 20 lbs: 1.Remove one dose applicator tube from package andadminister the entire contents of the tube that correctly corresponds to the body weight of the dog.2.While holding the tube in an upright position, remove the cap from the tube. 3.Turn the cap over and push the other end of cap onto the tip of the tube. 4.Twist the cap to break the seal and then remove the cap from the tube. 5.The dog should be standing for application.6.Part the hair on the back of the dog between the shoulder blades until the skin is visible. Do not apply an amount of solution at any one location that could run off the side of the dog. 7.Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. For dogs larger than 20 lbs: For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at three or four spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking.* Dogs over 88 lbs. should be treated with the appropriate combination of Advantage Multi for Dogs tubes. Advantage Multi Dog 3-9 lbs – 6 Doses. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.