Denosyl and Marin support the liver through differing actions and may be used individually or in combination. Denamarin is one such patented combination liver supplement for dogs and cats containing both pure and stabilized S-Adenosylmethionine SAMe and silybin-phosphatidylcholine complex. Both SAMe and silybin have been shown to markedly increase levels of antioxidants formed when cats and dogs metabolize it. Silybin also helps with liver cell regeneration and enhances levels of glutathione, the liver&rsquos major &ldquodetoxifying&rdquo agent. Denamarin has no known side-effects. Directions for Use:Tablets should be given on an empty stomach at least one hour before a meal for optimal absorption overnight fast preferred. For owners who find it difficult to administer tablets to their pets, Denamarin tablets may be disguised in a small bite of food. The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian. For Dogs of All Sizes Body Weight Number of Chewable Tablets Per Day Up to 6 lbs ¼ 7-15 lbs ½ 16-30 lbs 1 31-45 lbs 1 ½ 46-60 lbs 2 61-75 lbs 2 ½ 76-90 lbs 3 91-105 lbs 3 ½ Over 105 lbs 4 Small Tablet:For small dogs and cats = up to 12 pounds Medium Tablet:For medium dogs = 13 to 34 poundsLarge Tablet:For large dogs = 35 to 65 pounds For large dogs 66 to 120 pounds give 2 tablets of the large sizeFor large dogs over 120 pounds give 3 tablets of the large size. Storage: Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled. Denamarin Chewable Tablets for Dogs of All Sizes 30 cnt. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.