Dosage and Administration: Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment see Table 1. Table 1 Dosing Table Dosage Body weight 2 mcg/kg 4 mcg/kg 136 – 340 kg300 – 749 lb 0.5 tablet 1 tablet 341 – 567 kg750 – 1,249 lb 1 tablet 2 tablets 136 – 340 kg300 – 749 lb 1.5 tablets 3 tablets 341 – 567 kg750 – 1,249 lb 2 tablets 4 tablets Dosing should be titrated according to individual response to therapy to achieve the lowest effective dose. Dose titration is based on improvement in clinical signs associated with Pituitary Pars Intermedia Dysfunction PPID and/or improvement or normalization of endocrine tests for example, dexamethasone suppression test or endogenous ACTH test. If signs of dose intolerance develop, the dose should be decreased by half for 3 to 5 days and then titrated back up in 2 mcg/kg increments every 2 weeks until the desired effect is achieved. Contraindications: Prascend is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives. Warnings: Do not use in horses intended for human consumption. Human Warnings: Not for use in humans. Keep this and all medications out of the reach of children. Prascend should not be administered by persons who have had adverse reactions to ergotamine or other ergot derivatives. Pregnant or lactating women should wear gloves when administering this product. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when Prascend Tablets are split or crushed. Prascend Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. Consult a physician in case of accidental ingestion by humans. Prascend 1mg 60 count. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.