Advantage Multi® for Cats (imidacloprid + moxidectin)Topical Solution Advantage Multi for Cats combines 100 percent prevention of heartworm disease, as shown in clinical trials, with the flea control of Advantage®, and the treatment and control of intestinal worms (hookworm and roundworm) – all in one, convenient, monthly topical solution. Advantage Multi for Cats also treats and controls ear mite infestations. Key Benefits: 100 percent effective at preventing heartworm disease caused by Dirofilaria immitis, as shown in clinical trials. Up to 100 percent effective treatment and control of hookworm infections caused by Ancylostoma tubaeforme (adults, immature adults, and fourth stage larvae) and roundworm infections caused by Toxocara cati (adults and fourth stage larvae). Proven effective (up to 99.5 percent) treatment and control of ear mite (Otodectes cynotis) infestations. Safe and effective, when used topically as directed, for cats and kittens that are at least nine weeks of age and that weigh at least two pounds. Once-a-month, ready-to-use topical solution packaged in six, single-dose applicator tubes for cats weighing 5.1 to nine pounds and 9.1 to 18 lbs. Three, single-dose applicator tubes are available for cats/kittens weighing two to five pounds. Important Safety Information Like all topical animal health treatments, Advantage Multi for Cats, is not to be given to pets orally, is not for human use, and should be kept out of the reach of children. Oral ingestion by cats may result in hypersalivation, tremors, vomiting, and decreased appetite.; Children should not come in contact with the application site for 30 minutes after application. Ask your veterinarian if this product is right for your cat. How it works Advantage Multi® (imidacloprid + moxidectin) Topical Solution is to be administered monthly, and when applied directly to your pet's skin, prevents heartworm disease, kills adult fleas and controls flea infestations, and treats and controls intestinal worms. The two active ingredients in Advantage Multi are imidacloprid and moxidectin. Imidacloprid has a high affinity for the nicotinic acetylcholine receptors in the post-synaptic region of the nervous system of fleas. The ensuing inhibition of cholinergic transmission in insects (i.e., fleas) results in paralysis and death. Moxidectin interacts with gaba-amniobutyric acid (GABA) and glutamate-gated chloride channels. This leads to opening of the chloride channels on the post-synaptic junction, the inflow of chloride ions and induction of an irreversible resting state. The result is flaccid paralysis of susceptible parasites, followed by their death and/or expulsion. How to apply – Cats Pets and their owners alike will be excited by the convenience of Advantage Multi® for Cats (imidacloprid + moxidectin) Topical Solution. Your veterinarian will determine the correct dosage for your cat by his/her weight. Once a month, the pre-measured dose is applied to the surface of the cat's skin. Applying Advantage Multi for Cats is available in three convenient package sizes which offer flexibility in dosing: Kittens/Cats 2-5 pounds Cats between 5.1 and 9 pounds Cats between 9.1 and 18 pounds Once you have the correct pre-measured dose from your veterinarian, follow the instructions below to provide your purr-fect companion with fast relief: Dosage and Administration The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45mg/lb (1.0mg/kg) moxidectin, once a month by topical administration. Do not apply to irritated skin. Remove one dose applicator tube from package. As specified in the following table, administer the entire contents of the tube that correctly corresponds to the body weight of the cat. * Cats over 18 lbs. should be treated with the appropriate combination of Advantage Multi for Cats tubes. While holding the tube in an upright position, remove the cap from the tube. Turn the cap over and push the other end of cap onto the tip of the tube. Twist the cap to break the seal and then remove the cap from the tube. Part the hair on the back of the cat's neck at the base of the head until the skin visible. Place the tip of the tube on the skin and apply the entire contents directly on the exposed skin. Lift the tube away from skin before releasing pressure on tube. Do not get this product in the cat's mouth or eyes, or allow the cat to lick the application site for 30 minutes. Treatment at the base of the head will minimize the opportunity for ingestion by grooming. In households with multiple pets, keep animals separated to prevent licking of the application site. Stiff, matted hair or a damp, oily appearance of the hair may be observed at the application site on some cats. This is temporary and does not affect the safety and effectiveness of the product. Advantage Multi Cat 9.1-18 lbs – 12 Doses. I do not receive this product or any others in exchange for this article, I do get a commission for readers clicking the buy now links which helps to differ the cost of hosting this blog and I sincerely hope this article site helps you with your search for Vet Approved Rx products.